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CURRICULUM VITAE

Jill Glasspool-Malone, PhD

  • Contact: E-mail: jill@cieloazure.com
  • Telephone: 770-735-1549
  • Address: 771 Mitchell Rd, Jasper, GA 30143

EMPLOYMENT:

Consulting 2001-2005

  • Gene Delivery Alliance, Inc. Consulting, research, development and intellectual property licensing firm.
  • One of two co-founders
  • Consulting service, Business and technology development planning.
  • Consulting services for Inovio, AS. (See http://www.inovio.com/) Business and technology development planning, USA incorporation/business set-up USA. (Inovio, Inc. was sold to Genetronics, Inc in 2005). See Genetronics press release for details
  • Intellectual property development and research at the University of Bern, Switzerland.
  • Contract work in grant and contract writing
  • Writing papers for publication

Co-Founder, Board of Director Member and Secretary of the board

  • Intradigm, Corp. 1999-2001. see www.intradigm.com
  • One of three co-founders. Incorporation set-up.
  • Helped to secure 2.3 million in V.C. funding, including monies from the Novartis Venture Fund.
  • Assisted in writing successful challenge grant to the Maryland State Dept of Business
  • Facilities set-up (laboratory, office), infrastructure set-up (pay-roll, insurance, admin, etc).
  • Business and technology development planning, including in-depth business plan and scientific plan
  • Successful marketing of Intradigm, Corp. to venture capitalists.

Senior Research Associate

  • CBCP (Clinical Breast Care Project), Dept. of Surgery, USUHS, Employee of the Henry M. Jackson Foundation. 8/00 to 2/01.
  • Laboratory manager and supervisor
  • Immunology, cell culture (cell lines/primary), gene transfer, genetic vaccination research, animal research (see published /abstracts below for research areas)
  • Set-up laboratory facilities for the Clinical Breast Care Project, including new facilities design
  • (laboratory, animal rooms, animal surgical suite, office suites) at Windber Research Institute. See http://www.wriwindber.org/
  • Worked closely with architect firm to design space.
  • Set-up equipment and laboratory purchases, including vendor price quotes, equipment specs.
  • Writing papers for publication

Research Specialist

  • University of Maryland at Baltimore 1/97 to 8/00.
  • Laboratory manager and supervisor
  • Immunology, cell culture (cell lines/primary, CTL and T cell proliferation assays), gene transfer, genetic vaccination research, animal research (mouse, rat, pig, primate) BSL2 work
  • Extensive laboratory skills
  • Laboratory and employee supervisory.
  • Managed laboratory regulatory needs including IACUC, radiation safety, biosafety, OSHA
  • Grant writing, budget writing, budget supervision, IACUC protocol writing.
  • Animal research, including non-human primates. Procedures, surgery, quality control, etc.
  • Writing papers for publication (see attached list)

Research Associate

  • University of California, Davis. 8/92 to 1/97
  • Laboratory manager and supervisor
  • Immunology, cell culture, gene transfer, genetic vaccination research, animal research (see published /abstracts below for research areas).
  • Extensive laboratory skills
  • Employee supervision
  • Grant writing, budget writing, budget supervision, IACUC protocol writing.
  • Animal research, including non-human primates. Procedures, surgery, quality control, etc.
  • Quality control on GLP experiments for California Regional Primate Research Center.
  • Writing papers for publication (see attached list)

Staff Research Associate and Animal Health Technician (AHT)

  • California Regional Primate Research Center, UC Davis 6/91-8/92.
  • Worked with non-human primates (baboons, macaques, etc.) in a research setting.
  • Surgical assist: including c-sections, wound treatments, etc.
  • Treatments and Procedures on non-human primates
  • Quality control of GLP
  • Behavioral studies on infant macaques for HIV drug studies.
  • Some GMP work.

Animal Behaviorist

  • UC Davis-Pharmacology department/California Regional Primate Research Center. 7/91 to 6/92.
  • Behavioral studies on macaques, using lab-top computers and ethograms.
  • Animal Protocol quality control
  • AHT quality control and supervision
  • Non-Human Primate/gorilla keeper.
  • Brookfield Zoo-9/89 to 3/91.
  • Animal husbandry and management
  • Animal treatment and surgical assist.
  • Animal records management and organization.

Zoo Keeper

  • Broofield Zoo, Illinois. 7/89 to 5/91 Avian and non-homan primates.

Behavioral Specialist/Manager.

  • San Diego Zoo and Wild Animal Park (CRES-Center for Reproduction of Endangered Species) -1/86 to 8/89.
  • Management of non-human primate research facilities for CRES
  • Training volunteers and employees to conduct behavioral studies and animal husbandry.
  • Facilities protocol writing and implementation
  • IACUC protocol maintenance, Facility liaison for USDA
  • Extensive behavioral studies on lion-tailed macaque reproductive behavior and mother/infants dyads.
  • Behavioral studies on non-human primates (lion-tailed macaques, lorises, drills)
  • Emergency husbandry and care of cheetahs.

EDUCATION

  • 2001- 2005: Doctor of Philosophy with a Concentration in Public Policy/Administration and a Specialization in Biotechnology, The Union Institute and University, Cincinnati, OH. Dissertation title: Policy Analysis and Survey of Academic Scientists, Addressing the Peer Review System Administered by the National Institutes of Health.
  • Internship in Science Policy at Research!America (in Fall, 2002)
  • University of Maryland, Baltimore. Graduate coursework in Medical Technology (1997-99).
  • University of California, Davis. Ph.D. program in Comparative Pathology Dept. Required coursework for program almost completed. (1994-1996) -ABD.
  • Consumnes College. Animal Health Tech Training. (1992-3)
  • University of California, San Diego. Bachelor of Arts, Anthropology, with an emphasis in behavior. June, 1989
  • University of California, Davis. Animal Science and Avian Science Major (two years undergraduate work).

ACADEMIC HONORS:

  • Keystone Symposia Conference Scholarship Award, Gene-based Vaccines: Mechanisms, Delivery Systems and Efficacy. April 10-15, 2002.
  • UC San Diego, Provosts Honor List (1987, 1988, 1989)
  • Consumnes River College, Sacramento Animal Health Tech. Scholarship. (1992).
  • University of Maryland, Baltimore. Honor list (1997-99).
  • University of California, Davis. Honor list (1995-1996)

TEACHING EXPERIENCE:

  • University of California, Davis. Lecturer.Animals Models for Research (Winter 1995).
  • San Diego Zoo (Center for the Reproduction of Endangered Species) 1988-89 Taught seminar series on primate behavior/behavioral data collection methods.
  • University of California, San Diego Evolution (Winter 1988). TA under Dr. S. Strum.

SPECIALITY POST GRADUATE COURSEWORK:

  • Walter Reed healthcare System, Department of Clinical Investigation 2000 Research Course. Certificate of completion
  • USUHS Rodent Handling and Techniques Laboratory. Nov 2000. Testing required and passed.
  • USUHS Animal Protocol Writing Workshop. Oct 2000. Certificate of completion.
  • CIPP 909 Research Ethics, University of Maryland, Baltimore Spring 1999
  • Primate handling course: testing required and passed University of Maryland, Baltimore 1999.
  • Biohazardous training course: testing required and passed University of Maryland, Baltimore 1997-1999.
  • Chemical training course: testing required and passed University of Maryland, Baltimore 1997-1999.
  • Radiation Training. Course: testing required and passed University of Maryland, Baltimore 1997-1999.
  • Annual Course in Flow Cytometry, Bowdoin College. June 6-13, 1998
  • Laboratory animal handling course University of California, Davis, 1994-1997
  • Biohazardous training course, University of California, Davis, 1994-1997
  • Chemical training course, University of California, Davis, 1994-1997
  • Radiation Training. Course-University of California, Davis, 1994-1997
  • Non-human Primate handling course, California Regional Primate Research Center 1992.

PUBLICATIONS:

PEER REVIEWED PAPERS:

1. Glasspool-Malone J. and Malone RW. Methods in Enzymology-Gene Therapy Methods. Enhancing direct in vivo transfection with nuclease inhibitors and pulsed electrical fields. 2002;346:72-91. PMID: 11883098

2. Glasspool-Malone J, et. al., Marked Enhancement of Macaque and Murine Respiratory Tissue Transfection by Aurintricarboxylic Acid. J Gene Med. 2002 May-Jun;4(3):323-2.

3. Drabick, J.J., Glasspool-Malone J., et. al. Increased efficiency of cutaneous transfection and polynucleotide immunization using in-vivo electroporation. Mol Ther 2001 Feb;3(2): 249-255.

4. Somiari S, Glasspool-Malone J, et. al. Theory and in vivo application of electroporative gene delivery. Mol Ther. 2000 Sep;2(3):178-87.

5. Glasspool-Malone J, et. al. Efficient nonviral cutaneous transfection. Mol Ther. 2000 Aug;2(2):140-6.

6. Glasspool-Malone J, Malone RW, "Marked Enhancement of Direct Respiratory Tissue Transfection by Aurintricarboxylic Acid" Human Gene Therapy 1999 Vol 10:10.

7. Berlyn KA, Ponniah S, Stass SA, Malone JG, et. al. Developing Dendritic Cell Polynucleotide Vaccination for Prostate Cancer Immunotherapy. 1999 J. of Biotechnology.

8. Bennett MJ, Aberle AM, Balasubramaniam RP, Malone JG, et. al. Cationic lipid-mediated gene delivery to murine lung: correlation of lipid hydration with in vivo transfection activity. Med Chem 1997 Dec 5;40(25):4069-4078

9. Freedland SJ, Malone RW, Borchers HM, Zadourian Z, Malone JG, et. al. Toxicity of cationic lipid ribozyme in human prostate tumor cells can mimic ribozyme activity. 1997 Biochemical and Molecular Medicine.

10. Malone JG, et. al. Mucosal immune responses associated with polynucleotide vaccination. Behring Institute Research Communications 1997 (No 98).

11. Balasubramaniam RP, Bennet MJ, Aberle AM, Malone JG, et. al. Structural and Functional Analysis of Cationic Transfection Lipids: The Hydrophobic Domain. Gene Therapy 1996 3(2) 163-72.

12. Bennett, M.J., Aberle, A.M., Balasubramaniam, R.P., Malone, J.G., et. al. Considerations for the design of improved cationic amphilphile-based transfection reagents Journal of Liposome Research. 1996. 6(3)

13. A. Aberle, Malone JG, et. al. Structural and Functional Analysis of Cationic Transfection Lipids. M. J. Bennett, R. P. Balasubramaniam, 1995 North American CF Conference, Dallas, Texas, October 12-15. Pediatric Pulmonology.

14. K. D. Bassler, P. Montbriand, M. Bennett, Malone JG, et. al. Genetic Immunization: Effects of Novel Priming and Boosting Strategies. 1995 North American CF Conference, Dallas, Texas, October 12-15. Pediatric Pulmonology.

15. Bennett MJ, Balasubramaniam RP, Bassler KD, Malone JG, et. al. Mechanistic Studies and Cationic Lipid Structure/Function Analysis Leading to Improved Polynucleotide Transfection. Journal of Investigative Medicine, V43 (S2) 330A.

16. Bennett MJ, Aberle AM, Balasubramaniam RP, Malone JG, et. al. PolyGum (TfxTM), a Novel Cationic Liposome Compound Class for use in In Vivo and In Vitro Polynucleotide Delivery. Clinical Chemistry. (1994) 40(12)2341.

17. Killam, K.F., Tarara, E., Malone, J., et. al. (1993) A two year study of cage behavior of monkeys made dependent on morphine and infected with SIV. NIDA Res. Monograph: Problems of Drug Dependence 141:63.

ABSTRACTS (selected- Those listed below are published).

18. Efficient rat lung transfection, transplantation and sustained transgene expression by plasmid/ATA electroporation. Schmid RA, Kubisa B, Ayuni E, Cecchini M, Wetterwald A, Glasspool-Malone J, et. al. American Thoracic Society, International Conference. Atlanta, Georgia, USA. May 17-22, 2002 .

19. Electroporation greatly enhances intradermal DNA vaccination. Glasspool-Malone J, et. al. Keystone Sympoisa Conference: Gene-Based Vaccines: Mechanisms, Delivery Systems and Efficacy. Breckenridge, CO April 10-15, 2002.

20. Imaging Gene Transfer distribution and efficiency in Lung. Cecchini M, Malone RW, Kubisa B, Wetterwald A, McDoncald R, Ayuni E, Glasspool-Malone J, et. al. Molecular Imaging in Cancer: Linking Biology, Function, and Clinical Applications In Vivo Lake Buena Vista, FL January 23-27, 2002.

21. Efficiency of cutaneous transfection and genetic immunization is greatly enhanced using in vivo electroporation. Glasspool-Malone J, et. al. International Gene Therapy Conference. Rhodos, Greece. August 6-16, 2000.

22. In vivo electropermealilization of murine and porcine skin enhances transfection efficiency and immunologic responses. Glasspool-Malone J, et. al. American Society of Gene therapy Conference. Denver CO, June 2000 (Selected for Presentation).

23. Increased Efficiency of Cutaneous Transfection Using In Vivo Electroporation in Murine and Porcine Models. Glasspool-Malone J, et. al. Cutaneous Gene Therapy: Problems and Prospects. NIH, Bethesda, MD March 23-24, 2000. (Selected for Presentation).

24. Marked Enhancement of skin Tissue Transfection by Aurintricarboxylic Acid in mice, rats, pigs and macaques. Glasspool-Malone J, et. al. Cutaneous Gene Therapy: Problems and Prospects. NIH, Bethesda, MD March 23-24, 2000.

25. Marked enhancement of direct respiratory tissue transfection by aurintricarboxylic acid (ATA). McDonald RJ, Glasspool-Malone J, et. al. Thirteenth annual Cystic Fibrosis Conference. Seattle, WA. Oct 7-10, 1999.

26. Aurintricarboxylic Acid enhances murine and macaque respiratory tissue transfection, and in vitro analysis indicates inhibition of nucleases is responsible for increased transfection activity. Jill Glasspool-Malone, et. al. Int. Gene Therapy Con. Crete, Greece. August 6-16, 1999.

27. Marked enhancement of direct respiratory tissue transfection by aurintricarboxlic acid. Glasspool-Malone J, et. al. American Society of Gene therapy Conference. Washington, DC June 7-9, 1999.

28. Developing dentritic cell polynucleotide vaccines for lentiviral disease. Malone JG et. al. American Society of Gene therapy Conference. Washington, DC June 7-9, 1999.

29. Feline like dendritic cells-isolation, culture and genetic modifiactions using monocytic precursors. Glasspool-Malone JG, et. al. Symposium on Dendritic Cells in Fundamental and Clinical Immunology. Pittsburgh, PA. September, 24-28, 1998.

30. Zonula Occludens Toxin (Zot) inhibits intracellular trafficking of luciferase DNA in susceptible cells. Watts TL, Malone JG, et. al. Molecular Mechanisms of Transcellular Signaling: From Membrane Receptors to Transcription Factors. Advanced Study Institute Conference sponsored by NATO August, 1998

31. Bennett MJ, Balasubramaniam RP, Aberle A, Crowe LM, Malone JG, et. al. Structural and Functional Analysis of Cationic Transfection Lipids. Cambridge Healthtech Institute's Second Annual Artificial Self-Assembling Systems for Gene Transfer, Boston MA. September 28-29, 1995.

32. Bassler, K.D., S.W. Barnett, P. Montbriand, B. Doe, J.G. Malone, et. al. (1995). Development and testing of intramuscular and mucosal polynucleotide vaccines. 1995 International Symposium on Clinical Immunology, July 20-23, 1995, San Francisco, California.

33. Bassler KD, Montbriand P, Torres JV, Malone JG, et. al. Development and Testing of Intramuscular and Mucosal Genetic Vaccines. American Federation for Clinical Research, Carmel, CA, February 8-11, 1995.

34. Bennett MJ, Aberle AM, Balasubramaniam RP, Malone JG, et. al. PolyGum (Tfx), A Novel Cationic Liposome Compound Class for Use in in vivo and in vitro Polynucleotide Delivery. The Genetic Revolution: The San Diego Conference of the American Association for Clinical Chemistry, Molecular Pathology Division, San Diego, CA, November 17-19, 1994.

PRESENTATIONS:

Electroporation and intradermal DNA vaccination. Glasspool-Malone J. Keystone Symposia Conference: Gene-Based Vaccines: Mechanisms, Delivery Systems and Efficacy. Breckenridge, CO April 10-15, 2002.

PATENTS ISSUED:

DNA vaccines for eliciting a mucosal immune response. Malone, RW. and Malone, JG US Pat. Ser. No. 6,110,898 issued 8/29/00. Rights assigned to inventors and negotiations for licensing in progress.

PATENTS SUBMITTED:

Compounds and Methods for Enhancing Direct In Vivo Gene Transfer. Glasspool-Malone, J and Malone RW. Provisional application filed with US PTO on 8/19/98. Full application filed Feb 14, 1999. National phase entered Feb. 2001.

In-vivo Electroporation for eliciting an immune response. Glasspool-Malone J, Drabick, J. and Malone RW. Provisional Patent filed Feb. 2000, full patent filed Feb. 2001.

DNA vaccines for eliciting a mucosal immune response. Malone J and Malone RW. Full application filed November, 1999. Continuation of issued patent.

PUBLISHED REPORTS:

Investment in Research Saves Lives and Money: Facts about Obesity. #6 in a series. Sponsored by Lasker/Funding First. Stacie Propst and Jill Glasspool-Malone. 2003

Investment in Research Saves Lives and Money: Depression. #7 in a series. Sponsored by Lasker/Funding First. Stacie Propst and Jill Glasspool-Malone. 2003

Investment in Research Saves Lives and Money: Facts about COPD. #8 in a series. Sponsored by Lasker/Funding First. Stacie Propst and Jill Glasspool-Malone. 2003